The 3rd Annual HIRN Investigator Meeting was held March 7 – 10, 2017 at the Hyatt Regency Hotel in Bethesda, MD.
The Meeting Program contains the meeting Agenda, Poster Abstracts, Sponsor and Exhibitor Information is available to download.
HIRN2017.-Meeting-Program.pdf (2 downloads)
The PDF’s of the HIRN 2017 Posters can be found securely here.
The Poster Session Summary contains a detailed summary of the posters presented including presenter, title, and affiliation (Consortium/PI).
HIRN2017.-Poster-Session.pdf (2 downloads)
| Date | Session | Title & Speaker(s) |
| March 7, 2017 | Meeting Welcome and Welcome Presentation | Welcome Raghu Mirmira, Indiana University HIRN2017.-Welcome.-Mirmira.pdf (0 downloads) “A Type 1 Diabetes Perspective: Science and Family“ Quinn Peterson, Harvard University HIRN-2017.-Q-Peterson.-Perspective-Wide.pdf (1 download) |
| March 8, 2017 | Meeting Welcome and Keynote Presentation I | Welcome Maike Sander, University of California, San Diego Session-1_1.-Welcome.pdf (0 downloads) Keynote Presentation 1 “Update on Human Pathology of Type 1 and Treatment Considerations” Matthias von Herrath, La Jolla Institute for Allergy and Immunology Session-1_2.-Keynote.-von-Herrath.pdf (0 downloads) |
| Session I: Phenotyping Islet Cells in Type 1 Diabetes |
Moderator: Raghu Mirmira, Indiana University Session-1_3.-Moderator.pdf (0 downloads) “The Human Pancreas Analysis Program (HPAP)” Klaus Kaestner, University of Pennsylvania Session-1_4.-Kaestner.pdf (0 downloads) “Bioenergetic Failure is a Common Feature of b Cells in Type 1 Diabetes (T1D) Patients” Scott Stimpson, University of Florida Session-1_5.-Stimpson.pdf (0 downloads) “Remnant b Cells in Recent-onset Type 1 Diabetes Have Essentially Normal Gene Expression and Function, “Investigating Type 1 Diabetes by Imaging Mass Cytometry” |
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| Session II: Modeling Islet Function and Survival |
Moderator: Maike Sander, University of California San Diego Session-2_1.-Moderator.-Sander.pdf (0 downloads) “Update from the Coordinating Center (CC) & Bioinformatics Center (BC)” Joyce Niland and John Kaddis, City of Hope Session-2_2.-CC.BC_.-Niland.-Kaddis.pdf (0 downloads) “Pancreatic Islet on a Chip: Micro-engineered Islet Chip for Pharmacological Screening of Diabetic Therapies” Alanna Gannon, Harvard University Session-2_3.-Gannon.pdf (2 downloads) “Islet-on-a-Chip: A Novel Approach to Enhance Islet Survival ex vivo” “Modeling MODY3 with Human Pluripotent Stem Cells” “PTPN22 is a Polyfunctional Regulator of Immune Signaling Pathways in Dendritic Cells” |
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| Session III: Cell Targeted Therapeutics |
Moderator: Mark Kay, Stanford University Session-3_1.-Moderator.-Kay.pdf (0 downloads) “Targeting therapeutics to Human Pancreatic Islets with CAR-T Regulatory Cells” Heshan Peiris, Stanford University Session-3_2.-Peiris.pdf (0 downloads) “Transcriptional Targeting of Human Alpha and Beta Cells Using Recombinant AAV” Feorillo Galivo, Oregon Health and Science University Session-3_3.-Galivo.pdf (0 downloads) “Novel Small Molecule Confers TXNIP Inhibition in Beta Cells” |
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| March 9, 2017 | Update from the Breakout Sessions |
Biomarkers and Diagnosis Chair: Carmella Evans-Molina, Indiana University HIRN2017.-Breakout.-Biomarkers.pdf (0 downloads) Disease Modeling Platform for Beta Cell Immune Interactions (in vivo) Co-Chairs: Michael Brehm, University of Massachusetts Medical School Leonard Shultz, The Jackson Laboratory HIRN2017.-Breakout.-Disease-Modeling.pdf (0 downloads) Human Immunity to Islets Chair: Megan Sykes, Columbia University HIRN2017.-Breakout.-Human-Immunity.pdf (0 downloads) In vitro modeling of Autoimmune Interactions between Beta Cell & Immune System The Alpha Cell in Type 1 Diabetes New Approaches to Therapies: Islet Cell Replacement, Immunotherapy, etc. |
| Keynote Presentation II | “Novel Pathways for Expansion of Functional Beta-Cell Mass” Chris Newgard, Duke University HIRN2017.-Keynote-II.-Newgard.pdf (0 downloads) |
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| Session IV. Beta Cell Proliferation |
Moderator: Andrew Stewart, Icahn School of Medicine at Mount Sinai
“Islet Cell Heterogeneity During Aging and Disease Revisited Using Novel Single Cell Technologies” “Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal Beta-Cell Proliferation” “Deoxyhypusine Synthase is Required for the Adaptive Proliferative Response of the Islet Beta Cell” “Small-molecules Promote Human β-cell Proliferation in an Insulin Resistance Environment” |
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| Session V. Triggers of Autoimmunity in Type 1 Diabetes |
Moderator: Decio Eizirik, ULB Center for Diabetes Research Session-5_1.-Moderator.-Eizirik.pdf (0 downloads) “Using Human Stem Cell-derived Thymic Epithelium to Remodel T1D Immune Tolerance” Audrey Parent, University of California San Francisco Session-5_2.-Parent.pdf (0 downloads) “Broad Repertoire of Autoreactive T Cells from the Islets of Donors with Type 1 Diabetes” Sally Kent, University of Massachusetts Medical School Session-5_3.-Kent.pdf (0 downloads) “Insulin B9-23 is a Diabetes-initiating Epitope for Human Immune Systems” “Autoimmunity as a Source of Endogenous Heterologous Alloimmunity” |
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| Session VI. Markers and Mediators of Cell Damage |
Moderator: Kevan Herold, Yale University Session-6_1.-Moderator.-Herold.pdf (0 downloads) “Interferon Alpha is a Catastrophic Feature of the Diabetic Islet Microenvironment” Clayton Mathews, University of Florida Session-6_2.-Mathews.pdf (0 downloads) “Elevations in Circulating Extracellular Vesicle miR-21 as a Biomarker of Developing Type 1 Diabetes Mellitus” Emily Sims, Indiana University Session-6_3.-Sims.pdf (0 downloads) “Islet Autoantibodies are Associated with Insulitis but Not Beta Cell Loss in Type 1 Diabetes” “Substantial b cell Compromise Exists Five Years before the Diagnosis of Type 1 Diabetes |
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| Session VII. Regulation of Islet Function and Plasticity |
Moderator: Doris Stoffers, University of Pennsylvania
“Hepatic-Islet Alpha Cell Axis Regulates Human Alpha Cell Proliferation” “Modulation of the Adaptive a-Cell Identity Changes Occurring upon b-Cell Loss” “Adaptation of the Insulin Secretory Response to Fasting Requires the Histone Demethylase Lsd1” “Leptin Acts through Delta-cells to Inhibit Insulin Secretion in Human Islets” |
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| Closing and Workshops | Trans-Network Committee (TNC) Closing Comments Mark Atkinson, University of Florida HIRN2017.-TNC-Closing.-Atkinson.pdf (0 downloads) Bioinformatics Center Workshop: Open Source Data Analysis John Kaddis, City of Hope HIRN-BC-Worskhop.-data_analysis_with_R.pdf (1 download) HIRN2017_BC_workshop_intro.pdf (0 downloads) Coordinating Center Workshop: Social Media for Scientists Layla Rouse, City of Hope HIRN2017. CC-Social-Media-Workshop.pdf (0 downloads) |
